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Contraindicated (1)pentobarbital will minimize the level or outcome of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or outcome of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Double brexpiprazole dose in excess of one-two